The immune and nervous system have numerous cooperation that direct general body wellbeing. The sensory system or nervous system is under consistent observing from both the innate and adaptive immunity. All through improvement and grown-up life, the resistant framework identifies and reacts to changes in cell character and neural connectivity. Deregulation of both innate and adaptive immunity, weakness of crosstalk between dup i.e. nervous system and immune system, and modifications in the arrangement of intrinsic invulnerable components can incline the central system (CNS) to autoimmunity and neurodegeneration
Ankylosing Spondylitis (AS) One of seronegative spondyloarthropathy which affects the spine leads to a severe limitation of movements. Among the Rheumatological diseases, the longest diagnosis delay is still found for AS. It is believed that Ankylosing Spondylitis is genetically inherited disease. Ankylosing spondylitis typically affects young adults, most commonly males (M: F = 3:1) in their second through fourth decades. It affects the Sacroiliac joints, spine, hip and less common in the knee.